When do izzie and alex break up

Luckily, Derek realized that his marriage with Addison was over, and he and Meredith got back together. This couple was painful to watch from the start, as George was never really that into Callie to begin with. They broke up because of their friendships with Izzie and Mark, which caused jealousy. They got back together after George's father died, and he clung to Callie in his grief.

They married quickly and privately, and it was clear that he soon regretted it. They divorced after George cheated on her with Izzie. Cristina wasn't looking for anything serious, but she couldn't help but develop feelings for Burke. They started hooking up, and she hid her pregnancy from him. He chose his career over her and they kept their relationship a secret. Despite a number of differences, they fell in love and started a real relationship.

Their romance was dysfunctional from the start and only got worse when Burke was shot in the arm and began to rely on Cristina to cover for him during surgery. Despite this, they still got engaged. He left her at the altar, breaking her heart, but it was really for the best for Cristina.

Amelia is the first person Owen has feelings for after Cristina leaves. Fans thought the pairing was a bit awkward, and that their chemistry didn't compare to what Owen had with Cristina. They basically both bonded over their struggles and, while it was nice for them to have someone to talk to, the romantic part of their relationship came off as forced.

They got married really quickly as people on this show often do , but divorced after they found out Amelia had a brain tumor that was affecting her decision-making. They've broken up and reconciled so many times that fans are generally over this pairing. George and Izzie were great as friends, but fans didn't like it when the writers made their relationship more complicated by writing them to develop romantic feelings for each other.

George hurt Callie by cheating on her with Izzie, which really put fans against the pairing. After taking multiple jibes, Callie told George it was because Izzie was in love with him. After Callie disclosed the fact that she was somewhat wealthy and was paying most of their bills herself and didn't mind doing so, a hurt George told Meredith, who told Izzie. Izzie used this information when making a snide remark about Callie, knowing it would hit a nerve. Infuriated at his indiscretion, Callie kicked George out of their hotel room after voicing her opinion that Izzie "had feelings" for George.

Upset and confused, George went to Izzie and Meredith's house with a bottle of bourbon and after getting drunk, Izzie and George slept together. The next day, George had no recollection of their intimacy the previous night and didn't remember until he was having lunch with Callie and her father. George confronted Izzie about it in a linen closet at the hospital and after they almost kissed, George left in a surge of guilt. Later, Izzie wanted to tell Callie but George insisted that it be kept a secret.

While dealing with the aftermath of her sexual encounter with George, Izzie was visited by the adoptive parents of the child she had given up years before. Hannah, now 11, is sick with leukemia and her donor for a bone marrow transplant had died the previous night. Izzie asked if she could meet Hannah, her parents agreed if Hannah wanted to. Izzie agreed to donate bone marrow to save her daughter's life, causing her emotional grief, Dr. Bailey helped Izzie keep her daughter a secret from the other interns and helped her during the beginning of the bone marrow harvest.

Hannah's parents informed Izzie that Hannah was tired and maybe Izzie could meet Hannah when she was better. Despite this, Izzie still agreed to donate bone marrow. George noticed Izzie crying earlier and went to find her. He stayed with her for the rest of the harvest, setting aside other emotions.

In the recovery room, Izzie confides in George that she has a daughter and says she needs their friendship to survive even though the sex wasn't tragic like the encounter with him and Meredith. George was still conflicted with his feelings for Izzie and his guilt in betraying Callie, he left Izzie crying in the room, only to return once he realized Izzie needed help as a friend. George came with Izzie when she saw her daughter for the first time, noting that Hannah had Izzie's eyes and mouth.

Following this, Izzie and George pretended that everything was fine, and continued to spend time together as friends. As Callie became more suspicious, she confronted Izzie and begged her to relinquish George which prompted Izzie to guiltily withdraw from him. She and George both realized they couldn't pretend their sexual encounter never happened, especially because their feelings for each other keep getting in the way.

The combination of all these factors leads George to decide to transfer to Mercy West. After George received a letter telling him he'd been accepted to Mercy West Medical Center , pending the results of the intern exam, Izzie tried to convince him not to leave by saying she had no romantic feelings towards him.

Izzie later admitted to George that she was in love with him, leaving him speechless. George later admitted he loved Izzie too, despite his strange reaction to her when she confessed her love to him. Their relationship was soon discovered by George's wife, Callie and the two got a divorce. After some time, George and Izzie realized that their relationship was not working as they had very little chemistry. They broke up but continued to have a close friendship. When Izzie was diagnosed with cancer, her mother Robbie visited the hospital, unaware of how bad the cancer was.

Before she left, she said to Izzie that she always knew she was too good for the trailer park. Izzie said she loved her mother, but they work better at a distance. Her grandmother had a tumor on her thyroid and eventually died of thyroid cancer.

She bonded fastest with George. After a rough start with Alex, she became friends with him too. Izzie bonded well with Alison , who was similar to Izzie. They had similar cancer, age, and treatment plans. On discovering Alison decided against surgery for her brain metastases and discovering the IL-2 therapy was working, Izzie was torn between having surgery or not.

She tried to get the opinion of Alex, Cristina, Meredith, and George. Cristina and Meredith did not agree with the surgery. With IL-2 therapy, after three months, the mets were gone. Alex said their life together was at stake and eventually urged for the surgery, however. She attended University of Washington School of Medicine. At the beginning of her internship, Izzie struggled with others' assumptions of her as an incompetent doctor, due to the fact that she used to be a lingerie model.

Izzie was a reasonably good doctor but when she cut Denny Duquette's LVAD wire, she was going to be suspended but instead quit. Alex Karev later convinced Bailey to talk to Izzie and make her come back which Bailey succeeded in doing. Bailey convinced the Chief to let her return but with a strict probation which doesn't allow her to have contact with patients and an inferiority to her fellow interns.

Izzie became dissatisfied with the limited amount of medical work she could do and frequently tried to push the boundaries of her probation. She even donated most of her money from Denny Duquette's check to a free clinic where she and Bailey often worked. During an emergency involving a ferry accident, Izzie saved a man's life by drilling burr holes into his skull with an ordinary drill in the field.

This prompted an impressed chief to take her off probation and allow her to finish the rest of the procedure by drilling more burr holes but this time with a real high-speed surgical drill. After using a tactic of assigning Izzie to a patient that would inevitably die, Izzie left obstetrics. Izzie decided to try going into cardiothoracic surgery but was met by a determined Cristina , who was also trying to make a career in the same department. She eventually decided that she was not suited for the specialty and stopped pursuing it.

After Bailey realized she had too many things to look after, she handed over the keys of the clinic to Izzie, giving it to her. When her interns and the others started to dislike being doctors since they were banned from surgery, Izzie set up a competition, won by Lexie.

When she realized that Denny appearing was because she was sick, the set up a competition to diagnose patient X. When she discovered that she had cancer and other people started to learn, she finally admitted herself as a patient, she just designed Meredith and Derek's wedding and was quizzed on medical trivia by Bailey.

She quickly got back on her feet and continued working as a surgeon, although some thought it was too soon and after concerns from Owen Hunt, Derek Shepherd and Alex, Izzie was fired during the merger with Mercy West, although the chief used the standard speech and claimed it was due to budget cutbacks. After this Izzie left a note in Alex's cubby and left him. She relocated to Baldwin City, Kansas and became a surgical oncologist. A more complete gallery with pictures of Izzie Stevens can be found here.

Grey's Anatomy Universe Wiki Explore. Community and Help. Nerdfightergirl Tooniee. The Shows. Grey's Anatomy Music Episodes. Music Episodes. Explore Wikis Community Central. Register Don't have an account? Izzie Stevens.

Edit source History Talk Do you like this video? Play Sound. Let's look at that tattoo up close and personal, shall we?

What are these? Oh, my God! How does anybody practice medicine hauling these things around? And what have we got back here? Glutes, right? Gather around and check out the booty that put Izzie Stevens through med school! Have you had enough, or should I continue, because I have a few more very interesting tattoos. You want to call me Dr. That's fine. Just remember that while you're still sitting on two hundred grand of student loans I'm out of debt.

She was so angry that she just wrote him a letter and left the irony of this form of breakup is not lost on us, Grey's fans. That was essentially the end of their relationship. Though Izzie did return later in Season 6 to try and rekindle things with Alex, he realized he deserved better than to be jerked around. He turned her down and Izzie was never to be seen or heard from again. That is, until now. He was going to ask her for a testimony to help Meredith keep her job, but the conversation led to the revelation that Izzie had used hers and Alex's frozen embryos they had saved when she had cancer, and they had twins -- Eli and Alexis.

Upon hearing that he had two children, Alex snuck away to see this family that he never knew he had and immediately fell back in love with Izzie. Afraid that he wouldn't be able to return to Kansas if he had to face the people he was hurting in Seattle, Alex wrote the closest people in his life a letter to explain why he had left them. Izzie was Alex's first true love, and the first person to truly push him to be a better man.

Jo deserves better than a breakup letter, but the fact that Alex ended up with Izzie feels in line with the early seasons of the show. Close Ad. Live TV.